Substrate Specificity of Acyltransferase Domains for Efficient Transfer of Acyl Groups
نویسندگان
چکیده
منابع مشابه
The sterol substrate specificity of acyl CoA: :cholesterol acyltransferase from rat liver.
Rat liver microsomes were incubated with various sterols suspended in Triton WR-1339, and the extent of esterification of these sterols by acyl CoA:cholesterol acyltransferase was determined. A 3 beta-hydroxyl group was required for esterification to occur. Furthermore, the rate of ester formation of campesterol was only 20% that of cholesterol, and the rates for sitosterol and stigmasterol wer...
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The mammalian RBC lacks de novo lipid synthesis but maintains its membrane composition by rapid turnover of acyl moieties at the sn-2 position of phospholipids. Plasma-derived fatty acids are esterified to acyl-CoA by acyl-CoA synthetases and transferred to lysophospholipids by acyl-CoA:lysophospholipid acyltransferases. We report the characterization of three lysophosphatidylcholine (lysoPC) a...
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ژورنال
عنوان ژورنال: Frontiers in Microbiology
سال: 2018
ISSN: 1664-302X
DOI: 10.3389/fmicb.2018.01840